简历
张益梅,女,1988.10
邮箱:yimeizhang@cqwu.edu.cn
个人简述
重庆“巴渝学者”青年学者,从事生物纳米材料及其在药物运输方面的研究4年。主持国家自然科学基金青年项目、重庆市科技局自然科学基金面上项目、重庆市教育委员会科学技术研究项目共4项,到账经费32万;发表SCI论文7篇。主讲《物理化学》《高分子化学》等本科生课程,主持市级教研教改项目1项,已协助指导药学专业2届共3名硕士研究生,毕业2人。拟承担药物制剂方向研究生教学和指导。
研究领域
生物纳米材料在药物递送中的研究
主持项目情况
1. 国家自然科学基金青年项目(21907012),近红外光触发的ROS响应的阳离子脂质基因载体的研究,2020.01-2022.12,22万;
2. 重庆市自然科学基金面上项目(cstc2019jcyj-msxmX0766),具有ROS响应和光控释放特性的靶向型脂质基因载体研究,2019.07-2022.06,10万;
3. 重庆市教育委员会科学技术研究项目(KJQN201901329),基于透明质酸生物相容材料作为可视智能基因载体的研究,2019.11-2022.10,4万;
4. 重庆市教育委员会科学技术研究项目(KJQN202201324),载有PD-L1抑制剂的肿瘤靶向纳米药物实现化疗和免疫协同治疗三阴性乳腺癌申报书,2022.11-2025.10,4万;
发表论文
1. Zheng Huang, Lixia Gao, Fang Guo, Dan Li, Yan Tang, Huaisong Hu, Yafei Luo, Dianyong Tang, Bochu Wang * and Yimei Zhang*. Novel prodrug supramolecular nanoparticles capable of rapid mitochondrial-targeting and ROS-responsiveness for pancreatic cancer therapy [J].New J. Chem., 2022, 46, 12632–12640.
2. Yi-Mei Zhang, Meng Xia, Rui Ao, Li-Xia Gao, Yan Tang, Jiu-Hong Huang, Ya-Fei Luo, Zhong-Zhu Chen, Bo-Chu Wang and Zheng Huang* . Smart Design of Mitochondria-Targeted and ROS-Responsive CPI-613 Delivery Nanoplatform for Bioenergetic Pancreatic Cancer Therapy [J]. Nanomaterials, 2021, 11, 2875.
3. Yi-Mei Zhang, Ji Zhang, *Yan-Hong Liu, Yu Guo, Xiao-Qi Yu *and Zheng Huang*.Zinc(II)-cyclen Coordinative Amphiphiles for Enhanced Gene Delivery[J]. RSC Adv., 2020, 10, 39842–39853.
4. Yi-Mei Zhang, Zheng Huang, Xiao-Ru Wu, Ji Zhang*, Yan-Hong Liu and Xiao-Qi Yu*. A small combinatorial library of lipidoids as gene delivery vectors [J]. ACS Appl. Nano Mater. , 2018, 1, 8, 3925-3934.
5. Yi-Mei Zhang, Zheng Huang, Ji Zhang*, Wan-Xia Wu, Yan-Hong Liu and Xiao-Qi Yu*. Amphiphilic polymers from ring-opening polymerization: a strategy for the enhancement of gene delivery [J]. Biomater. Sci., 2017, 5, 718-729.
6. Yi-Mei Zhang, De-Chun Chang, Ji Zhang*, Yan-Hong Liu, Xiao-Qi Yu*. Cyclen-based double-tailed lipids for DNA delivery: Synthesis and the effect of linking group structures [J]. Bioorg. Med. Chem., 2015, 23, 5756–5763.
7. Yi-Mei Zhang, Yan-Hong Liu, Ji Zhang*, Qiang Liu, Zheng Huang and Xiao-Qi Yu*. Cationic gemini lipids with Cyclen headgroups: interaction with DNA and gene delivery abilities [J]. RSC Adv., 2014, 4, 44261- 44268.
出版著作
无
获得荣誉和奖励情况
重庆市“巴渝学者计划”青年学者、永川区女性科创人才
指导学生获奖情况
无