个人简述

理学博士，副教授，硕士生导师，重庆市巴渝学者青年学者、永川区女性科创人才。主要从事有机合成方法学、药物合成研究。现主持国家自然科学基金青年项目1项、重庆市自然科学基金博士后项目1项、重庆市自然科学基金面上项目1项、重庆市教育委员会一般项目2项。近年来发表在“Org. Lett.、Chem. Commun.、Adv. Synth. Catal.、Chem. Eur. J.、Org. Chem. Front.、Chin. J. Chem.、J. Org. Chem.”等影响因子3.0以上的国际著名科技期刊上发表SCI研究论文20余篇。

研究领域

有机合成方法学、药物合成

主持项目情况

1. 国家自然科学基金青年项目，基于多组分反应及多重串联策略高效合成稠环吲哚类化合物，2020/01-2022/12, 25万、已结题、主持。

2. 重庆市科委博士后项目，基于Ugi多组分反应构建新型USP14抑制剂及其抗癌活性的研究，2019/10-2021/09, 10万、已结题、主持。

3. 重庆市科委面上项目，基于多组分反应及还原性可见光催化去芳构化策略合成多环吲哚衍生物、2022/09-2025/09，10万元、在研、主持。

4. 重庆市教委青年项目，Pd催化多组分串联反应构建稠环吲哚衍生物及其生物活性研究、2019/09-2022/09，4万元、已结题、主持。

5. 重庆市教委青年项目，基于多组分反应构建咪唑并吡啶衍生物及其抗癌活性研究，2022/09-2025/09，4万元、在研，主持。

发表论文

1.Chuan-Hua Qu,* Shan-Shan Chen, Lin Zhu, Yan Tang, Si-Si Zhang, Hong-Bo Peng, and Gui-Ting Song,* Organophotocatalytic Site-Selective Radical Deuteration at Sterically Hindered Benzylic Positions by Consecutive Hydrogen Atom Transfer, Adv. Synth. Catal. 2025, 367, e202401436.

2.Chuan-Hua Qu,* Lin Zhu, Shan-Shan Chen, Hong-Bo Peng, Si-Si Zhang, Gui-Ting Song,* Photoredox Hydroacylative Dearomatization of Indoles with Aromatic Carboxylic Acids, Adv. Synth. Catal. 2025, 367, e202401401.

3.Chuan-Hua Qu*, Shu-Ting Li, Jian-Bo Liu, Zhong-Zhu Chen, Dian-Yong Tang Jia-Hong Li*, Gui-Ting Song*, Site-Selective Access to Functionalized Pyrroloquinoxalinones via H‑Atom Transfer from N=Csp2−H Bonds of Quinoxalinones, Org. Lett. 2024, 26, 9244−9250.

4.Chuan-Hua Qu, Xiao Yan,  Shu-Ting Li,  Jian-Bo Liu,   Zhi-Gang Xu,   Zhong-Zhu Chen,   Dian-Yong Tang,   Huan-Xiang Liu*,  Gui-Ting Song *, Visible Light-Mediated Metal-Free Alkyl Suzuki-Miyaura Coupling of Alkyl Halides and Alkenylboronic Acids/Esters: A Green Method for the Synthesis Allyl Difluoride Derivatives, Green Chem., 2023, 25, 3453-3461.

5.Gui-Ting Song, Yuan Liu, Yong Li, Xin-Yue Hu, Shu-Ting Li, Jian-Bo Liu, Chuanhua Qu, Microwave-Assisted Copper Catalytic Decarboxylative Reductive Coupling of para-Quinone Methides with 3-Indoleacetic Acids: Rapid Access to Polycyclic Spiroindolequinone derivatives, Organic Chemistry Frontiers, 2023, 10, 1512-1520.

6.Chuan-Hua Qu, Run Huang, Yuan Liu, Tong Liu, Gui-Ting Song*, Bromine-radical-induced Csp2-H difluor-oalkylation of quinoxali-nones and hydrazones through visible-light-promoted Csp3-Br bond homolysis, Org. Chem. Front., 2022, 9, 4135–4145.

7.Chuan-Hua Qu, Li-Xia Gao, Yan Tang, Yuan Liu, Xiao-Qin Luo, Gui-Ting Song*, Metal-Free Reductive Coupling of para-Quinone Methides with 4-Cyanopyridines Enabled by Pyridine-Boryl Radicals: Access to Pyridylated Diarylmethanes with Anti-Cancer Activity, Chemistry-A European Journal, 2022, 28, e202200264.

8.Chuan-Hua Qu, Run Huang, Yong Li, Tong Liu, Yuan Chen, Gui-Ting Song*, Selective sulfonylation and isonitrilation of para-quinone methides employing TosMIC as a source of sulfonyl group or isonitrile group, Beilstein J. Org. Chem. 2021, 17, 2822.

9.Gui-Ting Song, Chuan-Hua Qu, Jin-Hong Chen, Zhi-Gang Xu, Cheng-He Zhou*, Zhong-Zhu Chen*, Synthesis of monofluorooxazoles with quaternary C–F centers through photoredox-catalyzed radical addition of methylene-2-oxazolines, Org. Biomol. Chem. 2020,18, 2223.

10.Gui-Ting Song, Chuan-Hua Qu, Jie Lei, Wei Yan, Dian-Yong Tang, Hong-yu Li*, Zhong-Zhu Chen*, Zhi-Gang Xu*,  A decarboxylative C(sp3)-N bond forming reaction to construct 4-imidazolidinones via post-Ugi cascade sequence in one pot, Adv. Synth. Catal. 2020, 362, 4084.

11.Gui-Ting Song, Chuan-Hua Qu, Jiang-Ping Meng, Zhi-Gang Xu, Cheng-He Zhou*, Zhong-ZhuChen*, Photoredox catalytic cascade radical addition/aromatization of methylene-2-oxazolines: mild access to C(sp3 )-difluoro-oxazole derivatives, Tetrahedron Letters, 2019, 60, 151246.

12.Gui-Ting Song, Yong Li, Jia Xu, Zhi-Gang Xu, Yong Ding, Jie Lei, Nicholas McConnell, Jin Zhu*,  Zhong-Zhu Chen*, Microwave-assisted facile construction of quinoxalinone and benzimidazopyrazinone derivatives via two paths of post-Ugi cascade reaction, Mol. Divers. 2019, 23, 137.

13.Gui-Ting Song, Nicholas McConnell, Zhong-Zhu Chen, Xiao-Fang Yao, Jiu-Hong Huang, Jie Lei, Hui-Kuan Lin, Brendan Frett, Hong-yu Li*, Zhi-Gang Xu*, Diversity-Oriented Synthesis of Functionalized Imidazopyridine Analogues with Anti-Cancer Activity through a Transition-Metal Free, One-pot Cascade Reaction, Adv. Synth. Catal. 2018, 360, 3655.

14.Gui-Ting Song, Zhi-Gang Xu, Dian-Yong Tang, Shi-Qiang Li, Zhi-Gang Xie, Hong-Liang Zhong, Zhi-Wei Yang, Jin Zhu, Jin Zhang*, Zhong-Zhu Chen*, Facile microwave-assisted synthesis of benzimidazole scaffolds via Ugi-type three-component condensation (3CC) reactions, Mol. Divers. 2016, 20, 575.

15.Gui-Ting Song, Shi-Qiang Li, Zhi-Wei Yang, Jian-Hui Yuan, Ming-Shu Wang, Jin Zhu, Zhong-Zhu Chen, Zhi-Gang Xu, Microwave-assisted synthesis of fused piperazine-benzimidazoles via a facile, one-pot procedure, Tetrahedron Lett. 2015, 56, 4616.

专利授权

1. 屈川华;宋桂廷;黄玖红，吡咯并䓬酮稠环衍生物及其合成方法与应用，ZL202111046190.7，2024-01-16.

2. 屈川华;宋桂廷;唐艳;高丽霞，二芳基甲基吡啶类化合物及其制备方法和应用，ZL202110898403.2，2024-08-09.

获得荣誉和奖励情况

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