黄政,男,湖北宜昌人,博士研究生,副教授,硕士生导师,重庆大学生物医学工程博士后,十大菠菜网正规平台副院长。主要从事药物递送系统等生物医用材料的设计与应用研究,开发了一系列适应于肿瘤微环境的多功能药物共递送载体,实现药物的可控释放,用于肿瘤的靶向化疗/光动力/免疫疗法等。主持重庆市自然科学基金面上项目等省部级科研项目6项,在化学工业出版社出版学术专著1部,获中国发明专利授权3项,近年来在J. Mater. Chem. B、Colloid. Surface. B、ACS Appl. Nano Mater.、Nanomaterials等国际期刊上发表研究论文20多篇。主持省部级教改项目2项,公开发表教改论文2篇。
教育和工作经历:
2024.01-至今,菠菜全讯白菜网,十大菠菜网正规平台(创新靶向药物国际研究院),副教授
2021.11-至今,重庆市中药研究院/重庆大学,博士后(导师:王伯初教授)
2020.09-2021.08,重庆市教育委员会,科学技术处,顶岗锻炼干部
2019.07-2023.12,菠菜全讯白菜网,十大菠菜网正规平台(创新靶向药物国际研究院),讲师
2018.07-2019.06,菠菜全讯白菜网,创新靶向药物国际研究院,讲师
2013.09-2018.06,四川大学,化学生物学,理学博士(硕博连读)(导师:余孝其教授)
2009.09-2013.06,四川大学,化学类,理学学士(导师:余孝其教授)
研究兴趣:
1. 药物递送
2. 生物医用材料
科研项目:
1.重庆市教育委员会科学技术研究项目重点项目(KJZD-K202201307),基于ALPHA和BMS-1的多功能共载纳米系统在PDT和ICB协同治疗三阴性乳腺癌中的应用,2022.10-2025.09,12万,主持;
2.重庆市人力资源与社会保障局博士后研究项目特别资助(2021XM3094),还原响应荧光自报告脂质前药的构建及其在药物/siRNA共传输中的应用,2022.07-2023.06,5万,主持;
3.重庆市科学技术局自然科学基金面上项目(cstc2020jcyj-msxmX0908),具有聚集诱导发光(AIE)特性的“核-壳”结构仿病毒基因载体研究,2020.07-2023.06,5万,主持;
4.重庆市教育委员会科学技术研究项目青年项目(KJQN201901341),具有pH/还原双重响应和示踪特性的阳离子脂质在基因递送中的研究,2019.11-2022.10,4万,主持;
研究论文:
1. Yimei Zhang, Shiyi Xiang, Yayi Wu, Can Yang, Dianyong Tang, Zhongzhu Chen and Zheng Huang*, Novel co-delivery nanomedicine for photodynamic enlarged immunotherapy by cascade immune activation and efficient immunosuppression reversion, Bioorg. Chem., 2024, 153, 107978.
2. Zheng Huang, Tong Xian, Xiangyi Meng, Huaisong Hu, Lixia Gao, Jiuhong Huang, Donglin Yang, Kepeng Ou, Bochu Wang, Yimei Zhang*, Multifunctional Novel Nanoplatform for Effective Synergistic Chemo-Photodynamic Therapy of Breast Cancer by Enhancing DNA Damage and Disruptions of Its Reparation, Molecules, 2023, 28, 6972.
3. Zheng Huang, Huaisong Hu, Tong Xian, Zhigang Xu, Dianyong Tang, Bochu Wang and Yimei Zhang*, Carrier-free nanomedicines self-assembled from palbociclib dimers and Ce6 for enhanced combined chemo-photodynamic therapy of breast cancer, RSC Adv., 2023, 13, 1617–1626.
4. Zheng Huang, Dan Li, Fang Guo, Tong Xian, Huai-Song Hu, Jia Xu, Ya-Fei Luo, Zhong-Zhu Chen, Bo-Chu Wang and Yi-Mei Zhang*, Mitochondria-targeted photosensitizer based nanoplatform loading glutathione inhibitor for enhanced breast cancer photodynamic therapy, Colloid. Surface. B, 2022, 220, 112956.
5. Zheng Huang, Lixia Gao, Fang Guo, Dan Li, Yan Tang, Huaisong Hu, Yafei Luo, Dianyong Tang, Bochu Wang* and Yimei Zhang*, Novel prodrug supramolecular nanoparticles capable of rapid mitochondrial-targeting and ROS-responsiveness for pancreatic cancer therapy. New J. Chem., 2022, 46, 12632–12640.
6. Yi-Mei Zhang, Meng Xia, Rui Ao, Li-Xia Gao, Yan Tang, Jiu-Hong Huang, Ya-Fei Luo, Zhong-Zhu Chen, Bo-Chu Wang and Zheng Huang*, Smart Design of Mitochondria-Targeted and ROS-Responsive CPI-613 Delivery Nanoplatform for Bioenergetic Pancreatic Cancer Therapy. Nanomaterials, 2021, 11, 2875.
7. Yi-Mei Zhang, Ji Zhang*, Yan-Hong Liu, Yu Guo, Xiao-Qi Yu* and Zheng Huang*, Zinc(II)-cyclen Coordinative Amphiphiles for Enhanced Gene Delivery. RSC Adv., 2020, 10, 39842–39853.
8. Zheng Huang, Dong-Mei Zhao, Xuan Deng, Ji Zhang*, Yi-Mei Zhang and Xiao-Qi Yu*. Functionalized asymmetric bola-type amphiphiles for efficient gene and drug delivery, Nanomaterials, 2018, 8, 115-133.
9. Zheng Huang, Yi-Mei Zhang, Qian Cheng, Ji Zhang*, Yan-Hong Liu, Bing Wang and Xiao-Qi Yu*, Structure–activity relationship studies of symmetrical cationic bolasomes as non-viral gene vectors, J. Mater. Chem. B, 2016, 4, 5575-5584.
10. Zheng Huang, Yan-Hong Liu, Yi-Mei Zhang, Ji Zhang*, Qiang Liu and Xiao-Qi Yu*, Cyclen-based cationic lipids containing a pH-sensitive moiety as gene delivery vectors, Org. Biomol. Chem., 2015, 13, 620-630.
联系方式:
电话:023-61162783
地址:重庆市永川区菠菜全讯白菜网B区格物楼C206
电子邮箱:zhenghuang@cqwu.edu.cn