简历

杨东林，男，1984.10

邮箱：dlyang@cqwu.edu.cn

个人简述

杨东林，中共党员，博士，副教授，生物医用材料、药理学专业硕士生导师。2014 年毕业于西南大学家蚕基因组生物学国家重点实验室，获得理学博士学位。2014至2015年在山西大学生物技术研究所开展了周围神经髓鞘形成及稳定过程中Periaxin与其他相关蛋白质之间的相互作用研究；2015年进入十大菠菜网正规平台（创新靶向药物国际研究院），建立了以肿瘤细胞和小鼠为模型研究抗癌小分子抑制剂的活性和分子机理；2017至2018年在意大利那不勒斯费德里克二世大学分子药学与医学生物技术学院进行博士后研究，主要从事酪氨酸蛋白激酶RET和丝/苏氨酸蛋白激酶Aurora B小分子抗癌药物的筛选和药物抗癌分子机制，2020至2022年为西南大学十大菠菜网正规平台在站博士后，开展了抗凋亡蛋白BCL2小分子抑制剂的筛选及抗癌机理分析。本研究团队科研经费充足，科研平台完善，技术体系成熟。曾先后承担的本科生课程有：药物与健康、微生物学、生物化学与分子生物学。

研究领域

目前主要研究方向为生物医用高分子材料在抗肿瘤药物中的作用，将具有生物相容性的医用高分子材料作为载体，化学结合或物理包裹抗肿瘤药物，通过细胞生物学、分子生物学和体内动物水平评价药物的活性、毒性，以期提高抗肿瘤药物的生物利用度，从而药物对全身的毒副作用。

主持项目情况

重庆市教育委员会科学技术研究重点项目，KJZD-K20200130，新型苯并咪唑衍生物调控DNA修复抑制三阴性乳腺癌的分子机制研究，2020/10-2022/09，10万元，在研，主持

发表论文

#代表第一作者，*代表通讯作者

1. Dong-Lin Yang #, Ya-Jun Zhang #, Jie Lei, Shi-qiang Li, Liu-Jun He,  Dian-Yong Tang, Chuan Xu, Ling-Tian Zhang, Jing-Yuan Wen, Hui-Kuan Lin, Hong-Yu Li*, Zhong-Zhu Chen*, Zhi-Gang Xu*. Discovery of fused benzimidazole-imidazole autophagic flux inhibitors for treatment of triple-negative breast cancer. European Journal of Medicinal Chemistry. 2022, 240:114565. 中科院1区，IF2022：7.10.

2. 张亚军#，黄玖红，何刘军，胡春生，杨东林*，陈中祝，唐典勇*. 去甲泽拉木醛通过调控细胞周期和自噬诱导的细胞凋亡抑制K562细胞生长的机制. 中国药理学通报. 2022, 38(2):215-222

3. Dong-Lin Yang # *, Ya-Jun Zhang #, Liu-Jun He, Chun-Sheng Hu, Li-Xia Gao, Jiu-Hong Huang, Yan Tang, Jie Luo, Dian-Yong Tang*, Zhong-Zhu Chen*. Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux. Biological Research. 2021, 54(1):27. 中科院2区，IF2022：7.63.

4. Ya-Jun Zhang, Dong-Lin Yang* , Hong-Xia Qin, Liu-Jun He, Jiu-Hong Huang, Dian-Yong Tang, Zhi-Gang Xu, Zhong-Zhu Chen, Yong Li*. DMAPT-D6 induces death-receptor-mediated apoptosis to inhibit glioblastoma cell through DNA damage by accumulating intracellular ROS. Oncology Reports. 2021, 45(3):1261-1272. 中科院3区，IF2022：4.14.

5. Ming Zhang#, Yong Ding, Hong‑Xia Qin, Zhi‑Gang Xu, Hai‑Tao Lan*, Dong‑Lin Yang* and Cheng Yi*. One-pot synthesis of substituted pyrrole–imidazole derivatives with anticancer activity. Molecular Diversity. 2019, 24(4):1177-1184. 中科院3区，IF2022：3.37.

6. Liu-Jun He#, Dong-Lin Yang*, He-Ying Chen, Jiu-Hong Huang, Ya-Jun Zhang, Hong-Xia Qin, Juan-Li Wang, Dian-Yong Tang and Zhong-Zhu Chen*. A novel imidazopyridine derivative exhibits anticancer activity in breast cancer by inhibiting Wnt/β‑catenin signaling. OncoTargets and Therapy. 2020, 13, 10097-10109. 中科院3区，IF2022：4.35.

7. He-ying Chen#, Liu-jun He#, Shi-qiang Li, Ya-jun Zhang, Jiu-hong Huang, Hong-xia Qin, Juan-li Wang, Qian-yin Li* and Dong-Lin Yang*. A Derivate of Benzimidazole-Isoquinolinone Induces SKP2 Transcriptional Inhibition to Exert Anti-Tumor Activity in Glioblastoma Cells. Molecules. 2019, 24(15). 中科院3区，IF2022：4.93.

8. Liu-Jun He#，Dong-Lin Yang#，Shi-Qiang Li，Ya-Jun Zhang，Yan Tang，Jie Lei，Brendan Frett，Hui-kuan Lin，Hong-yu Li*, Zhong-Zhu Chen* and Zhi-Gang Xu⁎. Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells. Bioorganic & Medicinal Chemistry. 2018, 26, 3899–3908. 中科院3区，IF2022：3.46.

9. Ya‑Jun Zhang#, Zhi‑Gang Xu, Shi‑Qiang Li, Liu‑Jun He, Yan Tang, Zhong‑Zhu Chen* and Dong‑Lin Yang*. Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways. Cancer Cell International. 2018,18 (90). 中科院2区，IF2022：6.43.

10. Donglin Yang# *, Lixia Pan, Zhongzhu Chen, Huihui Du, Bo Luo, Jie Luo, Guoqing Pan. The roles of microsporidia spore wall proteins in the spore wall formation and polar tube anchorage to spore wall during development and infection processes. Experimental Parasitology. 2018, 187, 93-100. 中科院4区，IF2022：2.13.

11. Donglin Yang#, Lixia Pan, Pai Peng, Xiaoqun Dang, Chunfeng Li, Tian Li, Mengxian Long, Jie Chen, Yujiao Wu, Huihui Du, Bo Luo, Yue Song, Rui Tian, Jie Luo, Zeyang Zhou, Guoqing Pan*. Interaction between SWP9 and Polar Tube Proteins of the Microsporidian Nosema bombycis and Function of SWP9 as a Scaffolding Protein Contribute to Polar Tube Tethering to the Spore Wall. Infection and Immunity. 2017, 85 (3), e00872-16. 中科院2区，IF2022：3.61.

12. Donglin Yang#, Guoqing Pan, Xiaoqun Dang, Yawei Shi, Chunfeng Li, Pai Peng, Bo Luo, Maofei Bian, Yue Song, Cheng Ma, Jie Chen, Zhengang Ma, Lina Geng, Zhi Li, Rui Tian, Cuifang Wei，Zeyang Zhou*. Interaction and assembly of two novel spore wall proteins of Microsporidia: Nosema bombycis and roles in adherence and infection tohost cell. Infection and Immunity. 2015, 83 (4): 1715-1731. 中科院2区，IF2022：3.61.

13. Donglin Yang#, Xiaoqun Dang, Rui Tian, Mengxian Long, Chunfeng Li, Tian Li, Jie Chen, Zhi Li, Guoqing Pan, Zeyang Zhou*. Development of an approach to analyze the interaction between Nosema bombycis (microsporidia) deproteinated chitin spore coats and spore wall proteins. Journal of Invertebrate Pathology. 2014, 115: 1-7. 中科院2区，IF2022：2.80.

14. Donglin Yang#, Xiaoqun Dang, Pai Peng, Mengxian Long, Cheng Ma, Junjie Jia Guowei Qin, Haijing Wu, Tie Liu, Xiaowei Zhou, Guoqing Pan, Zeyang Zhou*. NbHSWP11, a microsporidia Nosema bombycis protein, localizing in the spore wall and membranes, reduces spore adherence to host cell BME. The Journal of Parasitology. 2014, 100 (5): 623-632. 中科院4区，IF2022：1.34.

15. Yafei Luo#, Zhongzhu Chen, Zhigang Xu, Donglin Yang, Jin Zhang*, Dianyong Tang*. Theoretical insights into acetylene adsorption on nanoporous gold surfaces: Role of residual silver. Applied Surface Science. 2018, 434(15): 735-743. 中科院1区，IF2022：7.39.

16. Wenqiao Fan#, Yusong Jiang#, Meixia Zhang, Donglin Yang, Zhongzhu Chen, Hanchang Sun*, Xuelian Lan, Fan Yan, Jingming Xu, Wanan Yuan. Comparative transcriptome analyses reveal the genetic basis underlying the immune function of three amphibians' skin. Plos One. 2017, 12(12): e0190023. 中科院3区，IF2022：3.75.

17. Jun Wang# *, Dong-Lin Yang, Zhong-Zhu Chen, Ben-Fu Gou*. Associations of bodymass index with cancer incidence among populations, genders, and menopausalstatus: a systematic review and meta-analysis. Cancer Epidemiology. 2016, 42: 1-8. 中科院3区，IF2022：2.89.

18. Xiao-Yan Zhang#, Zhi-Wei Yang, Zhongzhu Chen, Jun Wang, Dong-Lin Yang, Ze Shen, Li-Li Hu, Jian-Wu Xie, Jin Zhang*, Hai-Lei Cui*. Tandeme copper-catalyzed propargylation/alkyne azacyclization/isomerization reaction under microwave irradiation: synthesis of fully substituted pyrroles. Journal of Organic Chemistry. 2016, 81(5):1778-1785. 中科院2区，IF2022：4.20.

19. Jie Chen#, Lina Geng, Mengxian Long, Tian Li, Zhi Li, Donglin Yang, Chao Ma, Haijing Wu, Zhengang Ma, Chunfeng Li, Guoqing Pan, Zeyang Zhou*. Identification of a novel Chitin-binding spore wall protein (NbSWP12) with a BAR-2 domain from Nosema bombycis (Microsporidia). Parasitology. 2013, 140(11): 1394-402. 中科院3区，IF2022：3.24.

20. Zhengang Ma#, Chunfeng Li, Guoqing Pan, Zhihong Li, Bing Han, Jinshan Xu, Xiqian Lan, Jie Chen, Donglin Yang, Quanmei Chen, Qi Sang, Xiaocun Ji, Tian Li, Mengxian Long, Zeyang Zhou*. Genome-wide transcriptional response of silkworm (Bombyx mori) to infection by the microsporidian Nosema bombycis. Plos One. 2013, 8(12):e84137. 中科院3区，IF2022：3.75.

21. Zhi Li#, Guoqing Pan, Tian Li, Wei Huang, Jie Chen, Lina Geng, Donglin Yang, Linling Wang, Zeyang Zhou*. SWP5, a Spore Wall Protein, Interacts with Polar Tube Proteins in the Parasitic Microsporidian Nosema bombycis. Eukaryotic Cell. 2012, 11(2): 229-237.

出版著作

1. 当代分子生物学理论与技术应用探索，副著，编写10万字，北京工业大学出版社，2020.05

2. 微孢子虫：机会性病原体，翻译第9和16章，共3.7万字，高等教育出版社，中国北京，2020.04

获得荣誉和奖励情况

1. 2021年事业单位工作人员年度考核中，被确定为优秀 

2. 在2021年度民主评议党员中，被评定为“优秀”  2022. 03

3. 2022. 05在2021年疫情防空保卫战中，成为同心“战役”志愿服务者  2022. 03

4. 在菠菜全讯白菜网第二届“药创杯”大学生创新创业大赛决赛中，荣获“优秀指导教师”  2021. 12

5. 2020-2021学年度荣获迪康药业奖“优秀教师”  2021. 10

6. 2018-2019年度被评为菠菜全讯白菜网年度“优秀教师”  2019. 09

7. 家蚕微孢子虫孢壁蛋白NbSWP7和NbSWP9的研究获得2015年西南大学优秀科技成果      2015. 06

8. 2013-2014学年科研工作表现优异，获得家蚕基因组生物学国家重点实验室“科研之星”一等奖  2014. 07

9. Development of an approach to analyze the interaction between Nosema bombycis (microsporidia) deproteinated chitin spore coats and spore wall proteins获得家蚕基因组生物学国家重点实验室“优秀研究生”一等奖  2013. 07

10. 2012-2013学年，荣获家蚕基因组生物学国家重点实验室“优秀研究生”一等奖  2013. 06

11. 2012年在“重庆微生物学会第二届论文交流”中获得二等奖  2012. 11

指导学生获奖情况

1. 获得“2022年全国大学生生命科学竞赛（科学探究类）”重庆赛区三等奖  2022. 07

2. 在“菠菜全讯白菜网第二届“药创杯”大学生创新创业大赛决赛”中荣获一等奖   2021. 12