郭兆元，男，工学博士。2021年6月毕业于四川大学生物材料工程研究中心生物医学工程专业。研究方向为生物医用材料，主要从事药物递送系统、多功能水凝胶、可降解高分子医疗器械的研发及其在生物医用领域的应用。已在Bioactive Materials、Biomacromolecules、Nano Today、Journal of Materials Chemistry B、Acta Biomaterialia等期刊发表相关SCI论文14篇。参与国家自然科学基金面上项目1项，主持四川省科技厅项目1项。2025年1月进入十大菠菜网正规平台（创新靶向药物国际研究院），从事教学和科研工作。

教育和工作经历：

2025.01-至今，菠菜全讯白菜网，十大菠菜网正规平台（创新靶向药物国际研究院），讲师

2022.08-2024.07，电子科技大学，材料与能源学院，博士后

2021.07-2022.06，四川大学，生物材料工程研究中心，科研助理

2018.09-2021.06，四川大学，生物医学工程专业，工学博士

科研项目：

1. 四川省科技厅，苗子工程，2018016，pH敏感型阿霉素纳米胶束的研制及抗肿瘤活性评价，2018.07至2019.07，2万元，结题，主持。

2. 国家自然科学基金委员会, 面上项目, 51973135, 原位捕获抗原并靶向淋巴结DCs细胞的高效肿瘤治疗递送系统, 2020-01-01 至 2023-12-31, 59万元, 结题, 参与。

近年研究论文：

1. Kang, T., Guo, Z.#, Lu, Y., Cun, J. E., Gao, W., Pu, Y., & He, B. Hybrid Hydrogels of Polyacrylamide and Self-assembly Photodynamic Nanoparticles with Diverse Adhesion for Infected Chronic Wound Healing[J]. Biomacromolecules, 2024, 25(11): 7475-7484.

2. Guo, Z., Zhang, Z., Zhang, N., Gao, W., Li, J., Pu, Y., He B., & Xie, J. A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing[J]. Bioactive materials, 2022, 15: 203-213.（ESI高被引论文）

3. Guo, Z., Bai, Y., Zhang, Z., Mei, H., Li, J., Pu, Y., Zhao N., Guo W., Wu F., He b., & Xie, J. Thermosensitive polymer hydrogel as a physical shield on colonic mucosa for colitis treatment[J]. Journal of Materials Chemistry B, 2021, 9(18): 3874-3884.

4. Guo, Z., Zhao, K., Liu, R., Guo, X., He, B., Yan, J., & Ren, J. pH-sensitive polymeric micelles assembled by stereocomplexation between PLLA-b-PLys and PDLA-b-mPEG for drug delivery[J]. Journal of Materials Chemistry B, 2019, 7(2): 334-345.

5. Zhang, Z., Pan, Y., Guo, Z., Fan, X., Pan, Q., Gao, W., Luo K., Pu Y,. & He, B. An olsalazine nanoneedle-embedded inulin hydrogel reshapes intestinal homeostasis in inflammatory bowel disease[J]. Bioactive Materials, 2024, 33: 71-84.

6. Tang, L., Guo, Z., Zhao, Q., Fan, X., Pu, Y., He, B., & Chen, J. A biodegradable Janus sponge for negative pressure wound therapy. Biomacromolecules, 2024, 25(4), 2542-2553.

7. Zhang, Z., Wang, L., Guo, Z., Sun, Y., & Yan, J. A pH-sensitive imidazole grafted polymeric micelles nanoplatform based on ROS amplification for ferroptosis-enhanced chemodynamic therapy[J]. Colloids and Surfaces B: Biointerfaces, 2024, 237: 113871.

8. Pu, Y., Fan, X., Zhang, Z., Guo, Z., Pan, Q., Gao, W., Luo, K., & He, B. Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease. Journal of Controlled Release, 2023, 354, 1-18.

9. Zhang, Z., Pan, Y., Cun, J. E., Li, J., Guo, Z., Pan, Q., Gao, W., Pu, Y., Luo, K., & He, B. A reactive oxygen species-replenishing coordination polymer nanomedicine disrupts redox homeostasis and induces concurrent apoptosis-ferroptosis for combinational cancer therapy. Acta Biomaterialia, 2022, 151, 480-490.

10. Mei, H., Zhang, X., Cai, S., Zhang, X., Zhang, Y., Guo, Z., Shi W., Chu R., Zhang K., Cao J., & He, B. Fluorocarbon-driven photosensitizer assembly decodes energy conversion pathway for suppressing breast tumor[J]. Nano Today, 2021, 41: 101305.

11. Jin, S., Pu, Y., Guo, Z., Zhu, W., Li, S., Zhou, X., Guo, W., & He, B. A double-layer dura mater based on poly (caprolactone-co-lactide) film and polyurethane sponge: preparation, characterization, and biodegradation study. Journal of Materials Chemistry B, 2021, 9(18), 3863-3873.