个人简述:

付丁强，湖北荆州人，于2018年在中国科学院成都生物研究所攻读博士，师从国家优秀青年基金以及国家万人计划获得者唐卓研究员，并于2022年获得药物化学博士学位。期间主要开展靶向蛋白降解药物的设计，合成及活性研究以及靶向DNA损伤修复通路的药物设计、合成及抗肿瘤活性研究。2022.07-2023.09期间在上海至本医疗科技有限公司从事医药研发工作。2023年09月进入十大菠菜网正规平台 (创新靶向药物国际研究院)，主要从事抗肿瘤以及色素过度沉着性疾病分子的设计、合成、筛选以及活性研究。目前以第一和共同第一作者已发表一区TOP论文SCI 论文多篇 (Journal of Medicinal Chemistry；European Journal of Medicinal Chemistry；Cell Reports Physical Science等 )，中国发明专利授权1 项 (授权号:CN113735824B)。

研究领域:

1. 基于靶点开发抗肿瘤以及色素过度沉着性疾病的药物；

2. 基于靶点和探针进行小分子靶向药物的筛选和开发；

发表论文:

1. Dingqiang Fu#, Yi Yuan, Fengming Qin, Yan Xu, Xin Cui, Guangxun Li, Shaohua Yao, Yun Deng, Zhuo Tang*. Design, synthesis and biological evaluation of tyrosinase-targeting PROTACs., European Journal of Medicinal Chemistry, 2021.10. DOI: 10.1016/j.ejmech.2021.113850. 

2. Yi Yuan#, Dingqiang Fu#, Yan Xu, Xuyang Wang, Xiongfei Deng, Shan Zhou, Feng Du, Xin Cui, Yun Deng, Zhuo Tang*. Pt(IV) prodrug as a potential antitumor agent with APE1 inhibitory activity. Journal of Medicinal Chemistry, 2022.11. DOI:10.1021/acs.jmedchem.2c01318. 

3. Yan Xu# , Dingqiang Fu# , Yi Yuan#, Yan Peng , Juan Dong , Feng Du , Xin Huang , Guangxun Li , Xiaohua Chen , Qiwei Wang , Zhuo Tang*. A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function. Cell reports physical science, 2022.09. DOI: 10.1016/j.xcrp.2022.101064. 

4. Dingqiang Fu#, Xing Li, Liwen Zhang, Xiaowei Dong, Pang, Fei. Qian. Wang*. The characteristics in Chinese NSCLC patients with different BRAF mutation Classes, 2023, .34. S236-S236. Annals of Oncology (ESMO). DOI10.1016/j.annonc.2023.09.2864 

5. Dingqiang Fu#. A novel quinoline-based colorimetric fluorescent probe for hydrogen sulfide. Journal of Chemical Research, 2020. DOI: 10.1177/1747519820924589.

6. Dingqiang Fu#, Li Yang , Wencai Huang. Synthesis of benzo［e］indolium-based fluorescence probe for naked-eye recognition of CN^-. Chinese Journal of Analysis Laboratory, EI，2018. DOI：10.13595/j.cnki.issn1000-0720.2018.0159

7. Yan Xu, Yi Yuan, Dingqiang Fu, Yi Fu, Shan Zhou, Wan-Ting Yang, Xu-Yang Wang , Guang-Xun Li, Juan Dong, Feng Du, Xin Huang, Qi-Wei Wang, Zhuo Tang*. The aptamer-based RNA-PROTAC. Bioorganic & Medicinal Chemistry. 2023.04.. DOI: 10.1016/j.bmc.2023.117299. 

8. Jin Huang, Guang-xun Li*, Gao-feng Yang, Dingqiang Fu, Xiao-kang Nie, Xin Cui, Jin-zhong Zhao, Zhuo Tang*. Catalytic asymmetric synthesis of N-substituted tetrahydroquinoxalines via regioselective Heyns rearrangement and stereoselective transfer hydrogenation in one pot, Chemical Science，2021.02. DOI: 10.1039/d0sc06264b. 

9. Gao-feng Yang, Guang-xun Li*, Jin Huang, Dingqiang Fu, Xiao-kang Nie, Xin Cui, Jin-zhong Zhao, Zhuo Tang*. Regioselective, diastereoselective, and enantioselective one-pot tandem reaction based on an in situ formed reductant: preparation of 2,3-disubstituted 1,5-benzodiazepine，Journal of Organic Chemistry, 2021. DOI: 10.1021/acs.joc.0c03064