十大菠菜网正规平台 - 菠菜全讯白菜网

简介

雷杰，男

个人简述

副研究员，硕士生导师，2018年毕业于中国科学院成都有机化学研究所，获博士学位。2018年8月至2020年8月，美国阿肯色大学医学院博士后，2020年11月进入西南大学博士后工作流动站。2020年10月进入十大菠菜网正规平台（创新靶向药物国际研究院）工作，承担《物理化学》、《仪器分析实验》、《有机化学》等课程，主持及参与省部级项目5项，发表高水平研究论文近30篇，获得优秀教师、优秀本科毕业论文指导教师、2022 年“双城青才校园先锋”等称号，指导2018级优秀本科毕业论文1人次、第八届国际“互联网＋”重庆赛区银奖2项。

研究领域

1）药物化学，小分子激酶抑制剂研究

2）绿色合成工艺及其方法学研究

主持项目情况

1. 重庆市自然科学基金博士后科学基金项目，在立项中，可见光催化药物活性分子二芳基甲烷官能化合成研究， 2021.10-2023.09，10万，主持；

2. 重庆市教育委员会科学技术研究项目，异腈多组分反应合成吲哚类生物碱及其生物活性研究，2021.10-2023.09，4万，主持；

3. 菠菜全讯白菜网人才引进项目，基于多组分反应设计新型氮杂环化合物及其活性研究，2020.11-2023.10，8万，主持。

4. 重庆市科学技术局（基础研究与前沿探索项目），去泛素化酶抑制剂的合成与活性研究， 2020.01-2023.12，参与（排名第二）

代表性学术论文

1. Lei Jie, Li SQ, Luo YF , Tang DY, Zhou CH, Xu ZG , Chen ZZ , Zn(OTf)2-Promoted Isocyanide-Based Three-Component Reaction: Direct Access to 2-Oxazolines and β-Amino Amides [J], J. Org. Chem., 2022, 87, 1188-11898. (二区) (2020-08-17)

2. Lei Jie, Ding Y, Zhou HY , Gao XY, Cao YH , Tang DY , Li HY, Xu ZG, Chen ZZ , Practical synthesis of quinolone drugs via a novel TsCl-mediated domino reaction sequence [J]. Green Chem., 2022, 24(15), 5755-5759. (一区) (2020-07-08) 10.1039/d2gc01689c

3. Lei Jie., He LJ, Tang DY, Wen JY, Yan W, Li HY*, Chen ZZ*, Xu ZG*, Solvent-Dependent Chemoselective and Stereoselective Approach to Synthesis of Spiro-γ-Lactams with Potent Anticancer Activity, Adv. Synth. Catal., 2021, 363(12), 2996-3000. (二区 ) （2021-04-06）

4. Lei, Jie, Xu J, Tang DY, Shao, JW, Li, HY.*; Chen, ZZ.*; Xu, ZG*. A concise and unexpected one-pot methodology for the synthesis of pyrazinone-fused pyridones[J]. Org. Chem. Front. 2020, 7(18):2657-2663. (一区) (2020-08-06)

5. Lei, Jie, Li, Y.; Xu, J.; Tang, DY.; Shao, JW.; Li, HY.*; Chen, ZZ.*; Xu, ZG*. An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water [J]. Green Chem. 2020, 22(12):3716-3720. (一区) (2020-05-25)

6 . Lei, Jie, Song, GT.; Luo, YF.; Tang, DY.; Yan, W.; Li, HY.*; Chen, ZZ.*; Xu, ZG.* Synthesis of indoline-piperidinones via a novel Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction [J] Org. Chem. Front. 2020, 7(5):737-741. (一区, 选为封面) (2020-01-22)

7 . Lei, Jie, Li, Y.; He, LJ.; Luo, YF.; Tang, DY.; Yan, W.; Lin, HK,; Li, HY.*; Chen, ZZ.*; Xu, ZG.* Expeditious access of chromone analogues via a Michael addition-driven multicomponent reaction [J] Org. Chem. Front. 2020,7(8):987-992. (一区) (2020-03-06)

8. Lei, Jie, Song, GT.; He, LJ.; Luo, YF.; Tang, DY.; Lin, HK.; Frett, B.; Li, HY.*; Chen, ZZ.*; Xu, ZG.* One-pot construction of functionalized aziridines and maleimides via a novel pseudo-Knoevenagel cascade reaction[J]. Chem. Commun. 2020,56(14):2194-2197. (二区) (2020-01-11)

9 . Lei, Jie, Xu, ZG,; Tang, DY.; Li,Y.; Xu, J.; Li, HY.*; Zhu, J.*; Chen, ZZ.* Acid-promoted one-pot synthesis of substituted furan and 6-methylpyrazin-2(1H)-one derivatives via allene intermediate formed in situ [J]. ACS Comb. Sci. 2018, 20(5):292-297. (二区) (2018-04-05)

10. Lei, Jie; Meng, JP.; Tang, DY.; Frett, B,; Chen, ZZ.*; Xu, ZG.* Recent advances in the development of polycyclic skeletons via Ugi reaction cascades [J]. Mol. Divers. 2018, 22(2):503-516. (四区) (2018-01-16)

11. Lei, Jie; Xu, ZG.; Li, SQ.; Xu, J.; Zhu, J.*; Chen, ZZ.* Synthesis of isoindolin-1-one derivatives via multicomponent reactions of methyl 2-formylbenzoate and intramolecular amidation [J]. Mol. Divers. 2016, 20(4):859-865. (四区) (2016-06-07)

12. Meng, JP.; Lei, Jie* Crystal structure of (E)-N-(2-(benzylamino)-2-oxo-1-(4-oxo-4H-chromen-3-yl)ethyl)-N-(4-bromophenyl)-3-chloroacrylamide hydrate, C27H22BrClN2O5 [J]. Zeitschrift für Kristallographie-NCS, 2018, 233:589-590. （SCI收录）

13. 雷杰，唐典勇，徐志刚，朱槿*，陈中祝*. 微波辅助高效合成吡啶并咪唑类衍生物 [期刊].化学研究与应用, 2018, 6:34-36.（核心期刊）(2018-04-06)

14. Chen, ZZ.; Li, SQ.; Zhang, YJ.; Tang, DY.; Meng, JP.; Lei, Jie; Hong-Yu Li, Xu, ZG. Synthesis of Pyridodiindoles with Anticancer Activity by a Three Component Cascade Condensation. Org. Lett. 2018, 20(24):7811-7815. (一区)

15. Song, GT.; McConnell, N.; Chen, ZZ.; Yao, XF.; Huang, JH.; Lei, Jie; Lin, HK.; Frett, B.; Li, HY.; Xu, ZG. Diversity-Oriented Synthesis of Functionalized Imidazopyridine Analogues with Anti-Cancer Activity through a Transition-Metal Free, One-pot Cascade Reaction [J]. Adv. Synth. Catal. 2018, 360(19):3655-3661. (二区)

16. Xu, ZG.; Li, SQ.; Meng, JP.; Tang, DY.; He, LJ.; Lei, Jie; Lin, HK.; Li, HY.; Chen, ZZ. Functionalized Spiroindolines with Anticancer Activity through a Metal-Free Post-Ugi Diastereoselective One-Pot Cascade Reaction [J]. Chem. Eur. J. 2018, 24(26):6732-6736. (二区)

17. He, LJ.; Yang, DL.; Li, SQ.; Zhang, YJ.; Tang, Y.; Lei, Jie; Frett, B.; Lin, HK.; Li, HY.; Chen, ZZ.; Xu. ZG. Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells [J]. Bio. Med. Chem. 2018, 26(14):3899-3908. (三区)

18. Xu, ZG.; Ding, Y.; Meng, JP.; Tang, DY.; Li, Y.; Lei, Jie,; Xu, C.,; Chen, ZZ. Facile Construction of Hydantoin Scaffolds via a Post-Ugi Cascade Reaction. Synlett 2018, 29(16):2199–2202. (四区)

19. Xu, J.; Li, Y.; Meng, JP.; Lei, Jie; Chen, ZZ.; Tang, DY.; Zhu, J.; Xu, ZG. Efficient microwave-assisted synthesis of fused benzoxazepine-isoquinoline derivatives via an Ugi reaction/tautomerization/intramolecular SNAr reaction sequence [J]. Tetrahedron Lett. 2017, 58(16):1640-1643. (三区)

20. Li, Y.; Lei, Jie; Xu, J.; Tang, DY.; Chen, ZZ.; Zhu, J.; Xu, C. A facile method for building fused quinoxaline-quinolinones via an acidless post-Ugi cascade reaction [J]. Chin. Chem. Lett. 2017, 28(3):541-545. (三区)

21. Li, Y.; Meng, JP.; Lei, Jie; Chen, ZZ.; Tang, DY.; Zhu, J.; Zhang, J.; Xu, ZG. Efficient synthesis of fused oxazepino-isoquinoline scaffolds via an Ugi, followed by an intramolecular cyclization [J]. ACS Comb. Sci. 2017, 19(5):324-330. (二区)

22 . Li, Y.; Lei, Jie; Chen, ZZ.; Tang, DY.; Yuan, H.; Wang, M.; Zhu, J.; Xu, ZG. Microwave-assisted construction of pyrrolopyridinone ring systems by using an Ugi/indole cyclization reaction [J]. Eur. J. Org. Chem. 2016, 2016(34):5770-5776. (三区)

23. Li, SQ.; Gao, HY.; Lei, Jie; Wang, J.; Xu, J.; Chen, ZZ.; Xu, ZG. Efficient and facile synthesis of fused benzimidazole-diazepinones and dibenzimidazole diazepines via a UDC strategy and the hydroamination of an alkyne [J]. RSC Adv. 2016, 6(10):8461-8464. (三区)

24. Zhang, GF.; Li, SS.; Lei, Jie; Zhang, GH.; Xie, XQ.; Ding, CR.; Liu, RH. An Efficient Biomimetic Aerobic Oxidation of Alcohols Catalyzed by Iron Combined with Amino Acids. Synlett 2016, 27(6):956-960. (四区)

25. Zhang, GF.; Lei, Jie; Han, XW.; Luan, YX.; Ding, CR.; Shan, S. N-Functionalized Amino Acids Promoted Aerobic Copper-Catalyzed Oxidation of Benzylic Alcohols in Water.[J] Synlett 2015; 26(6):779-784.(四区)

26. Li Y.; Huang, Z.; Xu, J.; Ding, Y.; Tang, DY.; Lei, Jie; Li, H. Y.; Chen, ZZ.; Xu, ZG. Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction. Beilstein, J. Org. Chem. 2020, 2020:663-669. (三区)

27. Song, GT.; Qu, CH.; Lei Jie, Yan, W.; Tang, DY.; Li, H. Y.; Chen, ZZ.; Xu, ZG. A Decarboxylative C(sp3)−N Bond Forming Reaction to Construct 4-Imidazolidinones via Post-Ugi Cascade Sequence in One Pot. Adv. Synth. Catal., 2020, 362(19), 4084-4091. (二区 ) (2020-10-6)

28. Dong-LinYang, Ya-JunZhang, Lei Jie, Shi-QiangLi, Liu-JunHe, Dian-YongTang, ChuanXu, Ling-TianZhang, JingyuanWen, Hui-KuanLin, Hong-yu Li, Zhong-Zhu Chen, Zhi-GangXu, Discovery of fused benzimidazole-imidazole autophagic flux inhibitors for treatment of triple-negative breast cancer Eur. J. Med. Chem. 2022, 240, 114565-114575. (2022-10-05)

出版著作

乌吉串联反应合成氮杂环化合物冶金工业出版社（国家级出版社） ISBN 978-7-5024-9029-4 雷杰徐嘉

获得荣誉和奖励情况

1，第十七届“振兴杯”全国青年职业技能大赛（职工组）第十七届“振兴杯”全国青年职业技能大赛（职工组）重庆赛区优胜奖；

2，2021-2022学年优秀教师；

3，2022年获得本科毕业论文优秀指导教师；

4，2022年菠菜全讯白菜网“双城青才校园先锋”称号

指导学生获奖情况

1，“酮”心“酮”行—喹诺酮类药物绿色高效合成技术先行者第八届中国国际“互联网+”大学生创新创业大赛重庆赛区银奖

2，恶性罕见肿瘤靶向创新药物的发现与临床前研究第八届中国国际“互联网+”大学生创新创业大赛重庆赛区银奖